CARBONIC-ANHYDRASE INHIBITORS - SYNTHESIS AND INHIBITORY PROPERTIES OF 1,3,4-THIADIAZOLE-2,5-BISSULFONAMIDE

Authors
SUPURAN CT CONROY CW MAREN TH
Citation
Ct. Supuran et al., CARBONIC-ANHYDRASE INHIBITORS - SYNTHESIS AND INHIBITORY PROPERTIES OF 1,3,4-THIADIAZOLE-2,5-BISSULFONAMIDE, European journal of medicinal chemistry, 31(11), 1996, pp. 843-846
Citations number
22
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
31
Issue
11
Year of publication
1996
Pages
843 - 846
Database
ISI
SICI code
0223-5234(1996)31:11<843:CI-SAI>2.0.ZU;2-X
Abstract
1,3,4-Thiadiazole-2,5-bissulfonamide was prepared from 2,5-dimercapto- 1,3,4-thiadiazole, by a modification of the reported literature proced ure, ie, via the sulfenamide. This compound is the lead molecule for d esigning important classes of pharmacological agents, such as benzothi adiazine diuretics, and it seems to behave as a strong inhibitor of th e zinc enzyme carbonic anhydrase (CA). Here we prove that the title co mpound is actually a weak CA inhibitor and try to explain why previous investigators obtained erroneous data.