SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF N,N-DIMETHYL-2-PROPEN-1-AMINE DERIVATIVES

Authors
DECONTI R GIMENEZ SMN HAUN M PILLI RA DECASTRO SL DURAN N
Citation
R. Deconti et al., SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF N,N-DIMETHYL-2-PROPEN-1-AMINE DERIVATIVES, European journal of medicinal chemistry, 31(11), 1996, pp. 915-918
Citations number
14
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
31
Issue
11
Year of publication
1996
Pages
915 - 918
Database
ISI
SICI code
0223-5234(1996)31:11<915:SABOND>2.0.ZU;2-C
Abstract
The synthesis of several 4-yl)-3-(4-X-phenyl)-N,N-dimethyl-2-propen-1- amine derivatives is described. These compounds are potential trypanoc ide agents with relative low acute toxicities. The inhibition of growt h of Escherichia cell by these drugs with different para-substitution on the phenyl moiety and their trypanocidal activities against epimast igote from Trypanosoma cruzi were investigated.