ANTIMICROBIAL ACTIVITY OF N-HYDROXYALKYL 1,2-BENZISOTHIAZOL-3(2H)-ONES AND THEIR THIONO ANALOGS

N-Hydroxyalkyl derivatives of 1,2-benzisothiazol-3(2H)-one and 1,2-ben zisothiazol-3(2H)-thione have been prepared and their antifungal and a ntibacterial activity evaluated. Several compounds were active against selected fungi and Gram-positive microorganisms. Interesting activity was observed against the anaerobic strain Clostridium perfringens. Ge nerally the more active compounds belong to the class of 1,2-benzisoth iazol-3(2H)-ones. The retardation matches R(M) of the compounds was al so evaluated but the results obtained show that lipophilicity has only a minor effect on the antimicrobial activity.