A PROSPECTIVE RANDOMIZED TRIAL OF 2 SOLUTIONS FOR INTRAPARTUM AMNIOINFUSION - EFFECTS ON FETAL ELECTROLYTES, OSMOLALITY, AND ACID-BASE STATUS

OBJECTIVE: Our purpose was to compare the effects of intrapartum amnio infusion with normal saline solution versus lactated Ringer's solution plus physiologic glucose on neonatal electrolytes and acid-base balan ce. STUDY DESIGN: Patients undergoing amnioinfusion for obstetric indi cations were randomized to receive normal saline solution or lactated Ringer's solution plus physiologic glucose at standardized amnioinfusi on rates. Data were collected prospectively on maternal demographics, course of labor, and maternal and neonatal outcome. Arterial cord bloo d was obtained for analysis of electrolytes, glucose, osmolality, lact ic acid, and blood gases. Control subjects with normal fetal heart rat e patterns, and clear amniotic fluid not receiving amnioinfusion were studied concurrently. RESULTS: Data were collected on 59 patients (21 normal saline solution, 18 lactated Ringer's solution plus physiologic glucose, and 20 controls). Maternal demographics, course of labor, an d neonatal outcome were similar in all three groups. Cesarean sections were performed more often in the amnioinfusion groups (33.3% for norm al saline solution, 38.9% for lactated Ringer's solution plus physiolo gic glucose) than in the control group (5.0%), p < 0.05. Cord arterial electrolytes, glucose, osmolality, lactic acid, and blood gases were not altered by amnioinfusion with either solution. CONCLUSION: Intrapa rtum amnioinfusion with normal saline solution or lactated Ringer's so lution plus physiologic glucose has no effect on neonatal electrolytes or acid-base balance.