J. Harnek et al., ISOLATED LIVER PERFUSION USING PERCUTANEOUS METHODS - AN EXPERIMENTAL-STUDY IN THE PIG, Cardiovascular and interventional radiology, 19(6), 1996, pp. 418-422
Purpose: To develop a method for isolated perfusion of the liver using
radiological methods. Methods: Twenty-one pigs, weighing about 20 kg,
were divided into three groups. By transjugular and transfemoral appr
oaches two occlusion balloons were placed in the inferior vena cava cr
anial and caudal, respectively, to the origin of the hepatic veins. On
e occlusion balloon was placed transfemorally in the common hepatic ar
tery. Another occlusion balloon was inserted in the main branch of the
portal vein via the transjugular-transhepatic approach in 11 pigs (gr
oups 1 and 2), and in 10 pigs (group 3) by a percutaneous transhepatic
route. After inflation of the balloons, patency of the isolated liver
circulation was evaluated by recirculation of Tc-99(m)-labelled human
albumin during 30 min. Blood tests were obtained after 1, 3, 5, 10, 1
5, and 30 min to evaluate leakage from the liver to the systemic circu
lation. Results: Increasing leakage to the systemic circulation from t
he isolated liver circulation was observed in groups 1 and 2. In the t
hird group the leakage was less than 10%. Conclusion: In an experiment
al animal model, isolated perfusion of the liver with minor leakage to
the systemic circulation may be achieved using radiological methods.