THE NERVOUS-SYSTEM IN SYSTEMIC-SCLEROSIS (SCLERODERMA) - CLINICAL-FEATURES AND PATHOGENETIC MECHANISMS

Although the skin and the internal organs are the main targets of syst emic sclerosis (SSc), the nervous system, which was considered seconda ry to the disease process, has been shown recently to be more involved . Few reports were available concerning the involvement of the nervous system until the beginning of this century when a case of localized s cleroderma that developed cranial nerve injury was described. This art icle discusses more recent reports revealing the importance of the rel ationship between SSc and the nervous system on a primary level.