QUINOXALINE CHEMISTRY .6. SYNTHESIS AND EVALUATION OF ANTIULCER AND GASTROPROTECTIVE ACTIVITY OF -[ARYLMETHYLMERCAPTO-3-R-SUBSTITUTED]QUINOXALINES, ARYLMETHYLSULFINYL-3-R-SUBSTITUTED]QUINOXALINES, PIPERAZINYL-3-R-SUBSTITUTED]QUINOXALINES

Therty compounds possessing quinoxaline structure bearing either subst ituted arylmethylmercapto-, arylmethylsulfinyl group or a piperazinyl moiety in position 2 were prepared in order to evaluate an antiulcer a nd gastroprotective activity in rat pylorus ligature, in comparison wi th omeprazole and ranitidine at the dose of 100 mg/kg after oral admin istration. Among the compounds of the first group one third showed a m oderate activity being about half potent as omeprazole whereas in the second group compound 5b exibited an activity superior to that of rani tidine accompanied with the lowest incidence of lesions and mortality and another compound (5i) was equiactive as ranitidine.