3,4-DIMETHOXY CINNAMIC ACID TERTIARY AMIDES - SYNTHESIS AND EVALUATION OF ANTIINFLAMMATORY AND ANALGESIC ACTIVITIES

In this study, eight compounds with cinnamoyl amide structure have bee n synthesized by dicyclohexylcarbodiimide / hydroxybenzotriazol method . The structures of the compounds were elucidated by UV, IR, H-1-NMR, mass spectroscopy and the elementary analysis. The antiinflammatory ac tivities of the synthesized compounds were determined by carrageenan-i nduced hind paw edema test in mice and the most active compounds were found to be the dimethyl, diethyl and morpholine amide derivatives. An algesic activities were determined by the modified ''Koster'' test; di isopentyl and morpholine amide derivatives have shown the highest acti vity.