DEXTROMORAMIDE PHARMACOKINETICS FOLLOWING SUBLINGUAL ADMINISTRATION

Authors
JONES TE MORRIS RG SACCOIA NC THORNE D
Citation
Te. Jones et al., DEXTROMORAMIDE PHARMACOKINETICS FOLLOWING SUBLINGUAL ADMINISTRATION, Palliative medicine, 10(4), 1996, pp. 313-317
Citations number
12
Categorie Soggetti
Medicine, General & Internal","Public, Environmental & Occupation Heath
Journal title
Palliative medicine → ACNP
ISSN journal
02692163
Volume
10
Issue
4
Year of publication
1996
Pages
313 - 317
Database
ISI
SICI code
0269-2163(1996)10:4<313:DPFSA>2.0.ZU;2-R
Abstract
The extent of absorption and other pharmacokinetic parameters of dextr omoramide following sublingual administration were assessed in five pa tients receiving chronic opioid analgesia. The use of the standard 5 m g tablet formulation was associated with negligible absorption in two patients, a prolonged time to peak concentration in the other three an d substantial variability in clearance. The study concluded that the s tandard tablet formulation cannot be recommended for sublingual use wh ere reliable, rapid onset analgesia is required.