THE GROWTH PECULIARITIES OF HUMAN AND MOU SE-TUMOR EXPLANTS AND ISOLATED TUMOR-CELLS UNDER THE INFLUENCE OF IMMUNOMODULATORS DIFFERENT NATURE

The influence of immunomodulators of different nature (rIL-2, thymalin , levamisole, interferon-alpha) on the growth of human and mouse tumou r explants and isolated tumour cells has been investigated. It was sho wn, that immunomodulators exert different effects on the growth of tum our explants and isolated cells depending on the nature, doses of immu nomodulators, and particular model of tumour growth used in the experi ments. Comparative analysis of immunomodulators' effects showed that r IL-2 has the greatest identity of action on the tumour cells and expla nts in various model systems. Revealed differences of immunomodulators effects testify to a necessity to determine individual sensitivity of human tumors to immunomodulators, irrespective of their nature.