A Border collie was presented at the age of 9 weeks with several lesio
ns of the right forelimb, including a reddish-blue haemangiomatous mac
ula in the medio-dorsal part of the elbow, multiple, scattered small c
avernous haemangioma-like lesions at the plantar part of the foot and
a general hypertrophy of the limb. X-rays of the limb showed osteolysi
s. On skin biopsy, telangiectatic veins were observed. The rest of the
body did not show any skin lesions or hypertrophy. The dog was otherw
ise healthy. Due to the extension of the lesions and worsening of the
limb swelling, it was decided to amputate the affected limb. The dog r
emained healthy for 2 weeks, but then passed through episodes of anaem
ia, and finally died suddenly with signs of shock. Dissection of the l
imb after amputation revealed hypoplasia and aplasia of the deep venou
s system in the lower part of the leg. No arterio-venous shunts were n
oticed. in man, this syndrome, characterised by an insufficiently deve
loped deep venous system associated with local overgrowth of the limb
and cutaneous telangiectasia, is known as Klippel-Trenaunay syndrome.