EVOLUTION OF HEPATITIS-C VIRUS REINFECTIO N AFTER LIVER-TRANSPLANTATION

Objectives. - Hepatitis C virus recurrence is frequent after orthotopi c liver transplantation. The aim of this study was to evaluate the cli nical, biological, and histological characteristics of recurrence. Met hods. - One hundred and ten patients (91 males, mean age 49 years) wit h liver transplantation were followed up far more than 1 year (mean: 2 6 months, range: 12-71). Hepatitis C virus serologic 2nd generation te sts were performed before and every 3 months after transplantation in all patients. Serum RNA was detected every 6 months after transplantat ion by polymerase chain reaction. A percutaneous liver biopsy was perf ormed every year in all patients and in case of abnormal biological li ver tests. Results. - In 44 patients (40%), hepatitis C virus serology was positive before transplantation, and was unchanged after transpla ntation. In this group histologic chronic hepatitis was observed in 35 patients (79.5%). The mean Knodell score was 8.4 +/- 2.3, associated with an increase in serum aminotransferases (> twice the upper limit o f normal) in 26 cases (74.3%) and with serum RNA in 33 cases (94.3%). The Knodell score was not significantly higher 2 years or more after t ransplantation than before (9.5 +/- 3.9 vs 7.2 +/- 3.5). In 66 patient s with negative hepatitis C virus serology before transplantation, no changes were noted after transplantation. In this group, histologic ch ronic hepatitis was found in 14 cases (21.2%) associated with serum he patitis C virus RNA in 7 cases. Actuarial survival rates of the two gr oups were 97.1% and 91.2% at 2 years, and 93.5% and 86.7% at 5 years, respectively. No death clearly related to hepatitis C virus recurrence was observed. Conclusion. - Hepatitis C virus recurrence after liver transplantation is frequently associated with chronic hepatitis, and a progressive increase in liver lesions. Nevertheless, the 5-year survi val rates was not different in these patients compared to patients wit h negative hepatitis C virus serology before transplantation.