Mesenteric panniculitis is a rare disease involving the adipose tissue
of the mesentery. We report a case of a 27-year-old woman with mesent
eric panniculitis, who presented clinical and radiological features mi
micking Crohn's disease. In the outcome, she presented a small bowel p
erforation, unusual in this pathology, and an annexial involvement. Th
is case reminds us of the role of sepsis and repented abdominal surger
y in relation to the pathogenesis of mesenteric panniculitis. We repor
t the first case of mesenteric panniculitis mimicking Crohn's disease.