STUDY OF ANGIOTENSIN-II-INDUCED HYPERTENSIVE CHEMOTHERAPY FOR OVARIAN-CANCER IN RATS

We investigated the usefulness of angiotensin II (AT II)-induced hyper tensive chemotherapy for adenocarcinoma of the ovary, which was induce d with dimethylbenzantracene (DMBA) in rats. Ovaries with DMBA-induced cancer had poor blood flow, while normal ovaries had abundant brood f low when blood pressure was normal. The brood flow of the normal ovari es was suppressed by AT II-induced hypertension, while the blood flow in ovarian cancer was more than doubled. Tissue levels of the anticanc er drug cisplatin (CDDP) were almost the same in the normal ovary in t he presence or absence of induced hypertension. However, the CDDP leve l in ovarian cancer tissue was significantly higher with AT II-induced hypertension than with normotension. Comparison of the ratio of the e nlarged tumor to the primary tumor and the histopathologic antitumor e ffects, showed that AT II-induced hypertension treatment with CDDP was highly effective. Angiotensin II-induced hypertensive chemotherapy fo r adenocarcinoma of the ovary in rat was highly effective in compariso n with normotension.