THE 67 KD LAMININ-RECEPTOR IN HIGH AND LOW METASTATIC MELANOMA CELL-LINES

Four melanoma cell lines with different metastatic potential were used to study the expression of 67 kD laminin receptor (LnR) gene by tradi tional immunohistochemistry and polymerase chain reaction techniques. Intensive labeling of LnR protein was found in cells with high metasta tic potential. Also, the result from PCR and RT-PCR proved the correla tion between LnR gene and metastatic potential of melanoma cells in ad dition to other cell types from previous studies. It is, thus, suggest ed that the expression of LnR gene can be used as an early marker for the malignancy of melanoma cells.