THE EFFECT OF A SINGLE THERAPEUTIC DOSE OF CISPLATIN ON GFR IN DOGS

This study prospectively describes the late effect of a single dose of cisplatin on GFR in tumor-bearing dogs. GFR (measured by quantitative renal scintigraphy), BUN, creatinine, and urine specific gravity valu es were obtained in 19 tumor-bearing dogs prior to and four weeks afte r a single dose of cisplatin. Eleven tumor-bearing dogs were given a k nown non-nephrotoxic anticancer drug, dexniguldipine, as control. No s ignificant differences in pretreatment GFR, serum chemistry, or urinal ysis values were observed between cisplatin-treated and control dogs. GFR was significantly decreased four weeks following cisplatin adminis tration. The average percent change in GFR was -13.49% for all cisplat in treated dogs. No significant alterations of BUN, serum creatinine, or urine specific gravity were observed following treatment. In the co ntrol group, the average percent change in GFR was +3.98% which was no t significantly different from pretreatment values.