CHITOSAN-INDUCING HEMORRHAGIC PNEUMONIA IN DOGS

Authors
MINAMI S OHOKA M OKAMOTO Y MIYATAKE K MATSUHASHI A SHIGEMASA Y FUKUMOTO Y
Citation
S. Minami et al., CHITOSAN-INDUCING HEMORRHAGIC PNEUMONIA IN DOGS, Carbohydrate polymers, 29(3), 1996, pp. 241-246
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear","Polymer Sciences
Journal title
Carbohydrate polymers → ACNP
ISSN journal
01448617
Volume
29
Issue
3
Year of publication
1996
Pages
241 - 246
Database
ISI
SICI code
0144-8617(1996)29:3<241:CHPID>2.0.ZU;2-B
Abstract
Various amounts of chitosan (10-200 mg/kg) were administered subcutane ously to dogs. Anorexia and mortality were observed in dogs given dose s above 50 mg/kg, and above 150 mg/kg, respectively. In hematologic fi ndings leukocytosis and increasing of serum LDH(2) and LDH(3) isoenzym es were characteristic. From the findings of autopsy, severe hemorrhag ic pneumonia was observed in all dead dogs. Chitosan causes lethal pne umonia to dogs. Copyright (C) 1996 Elsevier Science Limited.