HIGHLY EFFICIENT SOLID-PHASE PHOSPHOPEPTIDE SYNTHESIS USING BIS-(POLYFLUOROPHENYL) CHLOROPHOSPHATES - PREPARATION OF SERINE-THREONINE PROTEIN PHOSPHATASE SUBSTRATES

Authors
HORMOZDIARI P GANI D
Citation
P. Hormozdiari et D. Gani, HIGHLY EFFICIENT SOLID-PHASE PHOSPHOPEPTIDE SYNTHESIS USING BIS-(POLYFLUOROPHENYL) CHLOROPHOSPHATES - PREPARATION OF SERINE-THREONINE PROTEIN PHOSPHATASE SUBSTRATES, Tetrahedron letters, 37(45), 1996, pp. 8227-8230
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
45
Year of publication
1996
Pages
8227 - 8230
Database
ISI
SICI code
0040-4039(1996)37:45<8227:HESPSU>2.0.ZU;2-R
Abstract
A new fast and efficient solid phase phosphorylation protocol suitable for the preparation of phosphoserine- and phosphothreonine-containing peptides is described. The method allows the facile conversion of pri mary and secondary alcohol groups to the corresponding bis-(pentafluor ophenyl) phosphate triesters which are cleanly converted to the phosph ate monoesters under acidic conditions. Copyright (C) 1996 Elsevier Sc ience Ltd.