The authors present a case of asystole occurring during dural closure
following craniotomy with the patient in the supine position. This 22-
year-old woman had a left parietal lobe tumor resected with bipolar ca
utery. Standard intraoperative monitoring with a left radial arterial
line and a right internal jugular central venous catheter was used dur
ing the surgery. The anesthetic course was complicated by intraoperati
ve bleeding that responded to three units of fresh frozen plasma. Prio
r to closure, the operative site appeared dry and intact. After closur
e, asystole occurred suddenly and resolved with evacuation of 500 ml o
f blood. It is speculated that the asystole was preceded by an acute i
ncrease in intracranial pressure and a subsequent secondary brainstem
compression.