ANTIREFLUX NIPPLES OR AFFERENT TUBULAR SEGMENTS IN 70 PATIENTS WITH ILEAL LOW-PRESSURE BLADDER SUBSTITUTES - LONG-TERM RESULTS OF A PROSPECTIVE RANDOMIZED TRIAL
Ue. Studer et al., ANTIREFLUX NIPPLES OR AFFERENT TUBULAR SEGMENTS IN 70 PATIENTS WITH ILEAL LOW-PRESSURE BLADDER SUBSTITUTES - LONG-TERM RESULTS OF A PROSPECTIVE RANDOMIZED TRIAL, The Journal of urology, 156(6), 1996, pp. 1913-1917
Purpose: Intestinal low pressure orthotopic bladder substitutes have n
o major coordinated contractions during micturition. Therefore, the im
portance and type of reflux prevention were assessed in a prospective
randomized study. Materials and Methods: A total of 70 patients with a
n ileal low pressure bladder substitute was randomized to receive a ni
pple valve or an isoperistaltic afferent ileal tubular segment for ref
lux prevention. Results: After median observation times of 57 and 45 m
onths, respectively, the results regarding functional reservoir capaci
ty, incidence of infected urine, urinary continence, voiding habits an
d serum electrolytes, urea and creatinine were similar in both groups.
Severe upper tract dilatation due to ureteroileal or nipple stenosis
occurred in 9 of 67 evaluable reno-ureteral units (13.5%) in patients
with antireflux nipples and in 2 of 69 (3%) in patients with an affere
nt tubular segment. This difference in favor of the latter cases is si
gnificant (Fisher's exact test p < 0.03). Video urodynamics did not sh
ow reflux of contrast medium during voiding in either group. A simulta
neous intravesical, intra-abdominal and intrapelvic pressure increase
was noted during the Valsalva maneuver. Conclusions: While long-term u
pper tract preservation by an afferent tubular ileal segment must be c
onfirmed in larger patient series with longer followup, our results in
dicate that reflux prevention in patients with orthotopic low pressure
bladder substitutes is not a major concern and does not justify the u
se of antireflux mechanisms with a high complication rate.