CYCLOPHOSPHAMIDE ASSOCIATED BLADDER-CANCER - A HIGHLY AGGRESSIVE DISEASE - ANALYSIS OF 12 CASES

Purpose: We gained knowledge of the etiology, treatment and prevention of cyclophosphamide associated urothelial cancer. Materials and Metho ds: The medical records of 6 men and 6 women (mean age 55 years) with cyclophosphamide associated bladder cancer were reviewed. Results: All tumors were grade 3 or 4 transitional cell carcinoma. Of the 5 patien ts initially treated with endoscopic resection alone only 1 is alive w ithout disease. Of the 6 patients who underwent early cystectomy 4 wer e alive at 24 to 111 months. The remaining patient with extensive canc er underwent partial cystectomy for palliation and died 3 months later . Conclusions: Cyclophosphamide associated bladder tumor is an aggress ive disease. However, long-term survival is possible when radical cyst ectomy is performed for bladder tumors with any sign of invasion and f or recurrent high grade disease, even when noninvasive.