Et. Fernandes et al., CYCLOPHOSPHAMIDE ASSOCIATED BLADDER-CANCER - A HIGHLY AGGRESSIVE DISEASE - ANALYSIS OF 12 CASES, The Journal of urology, 156(6), 1996, pp. 1931-1933
Purpose: We gained knowledge of the etiology, treatment and prevention
of cyclophosphamide associated urothelial cancer. Materials and Metho
ds: The medical records of 6 men and 6 women (mean age 55 years) with
cyclophosphamide associated bladder cancer were reviewed. Results: All
tumors were grade 3 or 4 transitional cell carcinoma. Of the 5 patien
ts initially treated with endoscopic resection alone only 1 is alive w
ithout disease. Of the 6 patients who underwent early cystectomy 4 wer
e alive at 24 to 111 months. The remaining patient with extensive canc
er underwent partial cystectomy for palliation and died 3 months later
. Conclusions: Cyclophosphamide associated bladder tumor is an aggress
ive disease. However, long-term survival is possible when radical cyst
ectomy is performed for bladder tumors with any sign of invasion and f
or recurrent high grade disease, even when noninvasive.