Dr. Archer et al., MYELINATION OF THE CANINE CENTRAL-NERVOUS-SYSTEM BY GLIAL-CELL TRANSPLANTATION - A MODEL FOR REPAIR OF HUMAN MYELIN DISEASE, Nature medicine, 3(1), 1997, pp. 54-59
Citations number
30
Categorie Soggetti
Medicine, Research & Experimental",Biology,"Cell Biology
There is a lack of effective means of promoting remyelination of the c
entral nervous system (CNS) in humans with chronic demyelinating disea
se. We have investigated the ability of transplanted glia to myelinate
areas of the CNS equivalent to focal demyelinated lesions in multiple
sclerosis (MS). In these studies we show that transplantation of olig
odendrocytes or their progenitors into the CNS of a neonatal or adult
canine myelin mutant results in repair of large areas similar in size
to many MS plaques. Progenitor or pre-progenitor cells of the oligoden
drocyte lineage have the greatest capacity for myelination following g
rafting, although cells of neonatal origin may also be used. Such an a
pproach may therefore have therapeutic value in the repair of focal le
sions in human myelin disease.