MYELINATION OF THE CANINE CENTRAL-NERVOUS-SYSTEM BY GLIAL-CELL TRANSPLANTATION - A MODEL FOR REPAIR OF HUMAN MYELIN DISEASE

Citation
Dr. Archer et al., MYELINATION OF THE CANINE CENTRAL-NERVOUS-SYSTEM BY GLIAL-CELL TRANSPLANTATION - A MODEL FOR REPAIR OF HUMAN MYELIN DISEASE, Nature medicine, 3(1), 1997, pp. 54-59
Citations number
30
Categorie Soggetti
Medicine, Research & Experimental",Biology,"Cell Biology
Journal title
ISSN journal
10788956
Volume
3
Issue
1
Year of publication
1997
Pages
54 - 59
Database
ISI
SICI code
1078-8956(1997)3:1<54:MOTCCB>2.0.ZU;2-F
Abstract
There is a lack of effective means of promoting remyelination of the c entral nervous system (CNS) in humans with chronic demyelinating disea se. We have investigated the ability of transplanted glia to myelinate areas of the CNS equivalent to focal demyelinated lesions in multiple sclerosis (MS). In these studies we show that transplantation of olig odendrocytes or their progenitors into the CNS of a neonatal or adult canine myelin mutant results in repair of large areas similar in size to many MS plaques. Progenitor or pre-progenitor cells of the oligoden drocyte lineage have the greatest capacity for myelination following g rafting, although cells of neonatal origin may also be used. Such an a pproach may therefore have therapeutic value in the repair of focal le sions in human myelin disease.