ANTITUMOR DIARYLSULFONYLUREAS - NOVEL AGENTS WITH UNFULFILLED PROMISE

Authors
HOUGHTON PJ HOUGHTON JA
Citation
Pj. Houghton et Ja. Houghton, ANTITUMOR DIARYLSULFONYLUREAS - NOVEL AGENTS WITH UNFULFILLED PROMISE, Investigational new drugs, 14(3), 1996, pp. 271-280
Citations number
34
Categorie Soggetti
Pharmacology & Pharmacy",Oncology
Journal title
Investigational new drugs → ACNP
ISSN journal
01676997
Volume
14
Issue
3
Year of publication
1996
Pages
271 - 280
Database
ISI
SICI code
0167-6997(1996)14:3<271:AD-NAW>2.0.ZU;2-W
Abstract
Diarylsulfonylureas represent a class of antitumor agent with signific ant therapeutic efficacy against rodent and human models of cancer. De spite the exciting preclinical activity of sulofenur, the prototypic a gent, clinical activity was poor. Here we review the activity of sulof enur and a second generation diarylsulfonylurea, LY295501 N-[5-(2,3-di hydrobenzofuryl) sulfonyl]-N'-(3,4-dichlorophenyl)urea, against colon tumor xenografts, and some of the cellular pharmacology of this class of antitumor agents.