We have isolated a genomic clone encoding human selenoprotein P includ
ing the putative promoter region. The gene spans 12 kb and consists of
five exons with a start codon in the second exon. A typical TATA sequ
ence, the recognition motifs for a GATA-binding factor and the liver-s
pecific factors, HNF-1 and HNF-3, were detected upstream from the tran
scription start point.