EXPRESSION, REGULATION AND POLYMORPHISM OF THE MXI1 GENES

The myc proto-oncogene family plays an important role in the control o f cellular growth and differentiation. Mxil, one of the Max-associated proteins, has been known to have an antagonistic action on Myc activi ty. The mxil mRNA increased during growth inhibition and differentiati on, and decreased with serum stimulation in mammal cell lines. We have also found an AAAAC polymorphic repeat in the 3' non-coding region of the human mxil cDNAs and a difference between the mxil mRNA half-live s in some different cell lines.