THE INTRON-EXON STRUCTURE OF THE PORCINE E-SELECTIN-ENCODING GENE

We have cloned and sequenced the gene encoding porcine E-selectin. The gene comprises 12 exons and 11 introns. Two pseudo-exons are containe d within intron 4 and intron 6. These sequences are similar to the cor responding exons in the human E-selectin sequence; however, they are n ot present in the porcine E-selectin-encoding cDNA. Transcription star ts at position -498 relative to the translation initiation site. The f irst ATG is located within exon 2. Translation stops in exon 11 leavin g exon 12 untranslated in its entirety.