THE EFFECT OF ETHER LIPID OCTADECYL-2-O-METHOXY-RAC-GLYCERO-3-PHOSPHOCHOLINE AND ITS ANALOGS PLATELET-ACTIVATING-FACTOR AND CARBAMYL-PLATELET-ACTIVATING-FACTOR ON THE BIOSYNTHESIS OF INTERLEUKIN-6 IN HUMAN THYMIC EPITHELIAL-CELLS CULTIVATED IN-VITRO

Authors
CARDILE V MASCARUCCI P DESIMONI MG JIANG XH BINDONI M
Citation
V. Cardile et al., THE EFFECT OF ETHER LIPID OCTADECYL-2-O-METHOXY-RAC-GLYCERO-3-PHOSPHOCHOLINE AND ITS ANALOGS PLATELET-ACTIVATING-FACTOR AND CARBAMYL-PLATELET-ACTIVATING-FACTOR ON THE BIOSYNTHESIS OF INTERLEUKIN-6 IN HUMAN THYMIC EPITHELIAL-CELLS CULTIVATED IN-VITRO, Cytokine, 8(9), 1996, pp. 698-701
Citations number
17
Categorie Soggetti
Cell Biology",Biology,Immunology
Journal title
Cytokine → ACNP
ISSN journal
10434666
Volume
8
Issue
9
Year of publication
1996
Pages
698 - 701
Database
ISI
SICI code
1043-4666(1996)8:9<698:TEOELO>2.0.ZU;2-3
Abstract
The effect of ether lipid Octadecyl-2-O-methoxy-rac-glycero-3-phosphoc holine (ET-18-OCH3), platelet activating factor (PAF) and carbamyl act ivating factor (CPAF) on the release of IL-6 in human thymic epitheliu m cultivated in vitro was studied. ET-18-OCH3 significantly increased the release of IL-6, giving the greatest effect at the dose of 2 mu g/ ml. PAF had no effect. The non-metabolizable CPAF was less effective t han ET-18-OCH3 and showed the greatest release of IL-6 at the dose of 1 mu g/ml. Ether lipid ET-18-OCH3 has a thymotrophic effect as has als o been demonstrated by other results obtained in our previous work. (C ) 1996 Academic Press Limited