THE THERAPEUTIC EFFECT OF A COMBINATION OF COFPROPAMINE, A CAFFEINE DERIVATIVE, AND CYCLOPHOSPHAMIDE ON THE DEVELOPMENT OF ADJUVANT ARTHRITIS OF RATS AND COLLAGEN ARTHRITIS OF MICE

Authors
KROGER H KLOSA J GRATZ R DIETRICH A EHRLICH W WILD A
Citation
H. Kroger et al., THE THERAPEUTIC EFFECT OF A COMBINATION OF COFPROPAMINE, A CAFFEINE DERIVATIVE, AND CYCLOPHOSPHAMIDE ON THE DEVELOPMENT OF ADJUVANT ARTHRITIS OF RATS AND COLLAGEN ARTHRITIS OF MICE, General pharmacology, 27(7), 1996, pp. 1215-1218
Citations number
23
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
General pharmacology → ACNP
ISSN journal
03063623
Volume
27
Issue
7
Year of publication
1996
Pages
1215 - 1218
Database
ISI
SICI code
0306-3623(1996)27:7<1215:TTEOAC>2.0.ZU;2-5
Abstract
1. Cofpropamine(Cofa), a caffeine derivative that inhibits polyadenori bosylation, enhances the therapeutic effect of cyclophosphamide (CPA) in two animal models of arthritis. 2. The development of adjuvant arth ritis of rats is reduced by treatment with 2 x 50 mg/kg IP CPA and 2 x 50 mg/kg IP Cofa. 3. The development of collagen arthritis in mice is prevented by treatment with 12.5 mg/kg IP CPA and 150 mg/kg IP Cofa t hree times per week. Copyright (C) 1996 Elsevier Science Inc.