EXAMINATION OF COUMARINS, FLAVONOIDS AND POLYSACCHAROPEPTIDE FOR ANTIBACTERIAL ACTIVITY

1. Coumarins, flavonoids and polysaccharopeptide were tested for antib acterial activity. 2. The bacteria used for this study included clinic al isolates of Staphylococcus aureus, Shigella flexneri , Salmonella t yphi, Escherichia coli and Pseudomonas aeruginosa. 3. Most of the coum arins tested failed to inhibit the bacteria at 25 mg/l. Edultin at 128 mg/l inhibited 4 of the 8 P. aeruginosa strains and 1 of the S. aureu s strains tested. O-acetylcolumbianetin and imperatorin did not inhibi t any isolate, even at 128 mg/l. 4. When tested at the dose of 128 mg/ l, the flavonoids (rutin, naringin and baicalin) inhibited 25% or less of P. aeruginosa and only baicalin was active against S. aureus. 5. A rbutin and 4-(beta-D-glucopyranosyloxyl)-benzaldehyde inhibited 3 of t he 8 P. aeruginosa strains when tested at 128 mg/l. 6. Polysaccharopep tide from the fungus Coriolus versicolor failed to inhibit any P. aeru ginosa or S. aureus strain at 128 mg/l. Copyright (C) 1996 Elsevier Sc ience Inc.