The status of priming on the general knowledge test was examined in am
nesia. Twenty amnesic and 20 control participants studied words (e.g.,
CHEETAH) under semantic and nonsemantic encoding conditions and attem
pted to answer general knowledge questions (e.g., ''What is the fastes
t animal on earth''?) under implicit and explicit retrieval instructio
ns. The measure of memory was how many more test questions participant
s answered correctly using studied than nonstudied words. Amnesic pati
ents showed impaired memory under implicit and explicit retrieval inst
ructions. Control participants showed equal memory under implicit and
explicit retrieval instructions, a result indicating that they engaged
in explicit retrieval in both instruction conditions. General-knowled
ge priming appears to involve explicit retrieval that depends on media
l-temporal and diencephalic regions damaged in amnesia.