EFFECTS OF DIALLYL SULFIDE AND DIALLYL DISULFIDE ON CISPLATIN-INDUCEDCHANGES IN GLUTATHIONE AND GLUTATHIONE-S-TRANSFERASE ACTIVITY

Authors
DWIVEDI C ABUGHAZALEH A GUENTHER J
Citation
C. Dwivedi et al., EFFECTS OF DIALLYL SULFIDE AND DIALLYL DISULFIDE ON CISPLATIN-INDUCEDCHANGES IN GLUTATHIONE AND GLUTATHIONE-S-TRANSFERASE ACTIVITY, Anti-cancer drugs, 7(7), 1996, pp. 792-794
Citations number
12
Categorie Soggetti
Oncology,"Pharmacology & Pharmacy
Journal title
Anti-cancer drugs → ACNP
ISSN journal
09594973
Volume
7
Issue
7
Year of publication
1996
Pages
792 - 794
Database
ISI
SICI code
0959-4973(1996)7:7<792:EODSAD>2.0.ZU;2-U
Abstract
The effects of diallyl sulfide (DAS) and diallyl disulfide (DADS) on c isplatin-induced changes in glutathione (GSH) and glutathione-S-transf erase (GST) activity in rat liver and kidney was investigated. Cisplat in treatment significantly (p < 0.05) decreased GSH and GST activity i n both river and kidney. DADS treatment significantly (p < 0.05) enhan ced GSH and GST activity in rat liver and kidney. Furthermore, DADS tr eatment reversed the effect of cisplatin on GSH and GST activity both in liver and kidney. Administration of DADS with cisplatin could enhan ce GSH and GST activity and lower cisplatin-induced nephrotoxicity.