Fifty-six patients with limb-threatening ischaemia had pedal revascula
rization with either autologous vein (n = 39) or sequential composite
graft with a 6-mm polytetrafluoroethylene prosthesis and autologous ve
in (n = 17); 75 per cent had gangrene and skin necrosis and 25 per cen
t had ischaemic rest pain alone. Twelve grafts occluded within the fir
st week, and resulted in major amputation in eight patients after unsu
ccessful revision. Two patients required amputation for persistent isc
haemia despite a patent bypass. One patient died from bowel perforatio
n (2 per cent). In 47 (84 per cent) of the 56 patients limb and life w
ere preserved. The primary patency rate after 1, 2 and 4 years was 65,
55 and 55 per cent respectively, the secondary patency rate was 71, 6
2 and 62 per cent, and cumulative limb salvage rates were 77, 71 and 6
6 per cent. Life-table survival rates during follow-up (median 25 (ran
ge 0-112) months) were 89, 78 and 52 per cent respectively after 1, 2
and 4 years. Thirteen of 21 patients who died during follow-up did not
require major amputation. Pedal reconstruction with autologous vein p
rovides limb salvage until death in nearly two-thirds of patients with
critical limb ischaemia resulting from crural arterial occlusive dise
ase.