IMMUNOGLOBULIN-A (IGA) DEPOSITS IN LESIONAL SKIN OF A PATIENT WITH BLEPHAROCHALASIS

We describe a 21-year-old male patient with blepharochalasis, a form o f localized acquired cutis laxa. He had a 13-year history of recurrent swelling attacks of the eyelids of unknown origin leading to periocul ar localized cutis laxa, Histology of lesional skin confirmed almost c omplete loss of elastic fibres in the reticular and papillary dermis. Immunofluorescence and immunoelectron microscopy studies showed abunda nt immunoglobulin A (IgA) deposits around the remaining elastic fibres . Control skin of the forearm was negative. These findings support the hypothesis that immunopathogenetic mechanisms may contribute to the e lastolytic process of blepharochalasis.