DYNAMIC CHANGES OF MECHANICALLY ACTIVATED CHANNELS AND K-NERVE IN RAT( CHANNELS AT INJURY SITE OF PERIPHERAL)

Ectopic ion channels developed locally at the injury site after nerve damage by light ligation around common sciatic nerve of the rats. Diff erent channel types have different processes of formation, accumulatio n and degeneration. During the first three days after injury, mechanic ally activated channels that are modulated by Ca++ channel activities first appeared. As the nerve fibers begin to be excited by TEA, a bloc ker of K+ channels, suggesting that the accumulation of K+ channels, t he responsibility of mechanically activated channels was declining. On set of K+ channels was from the 3rd postoperative day and lasted up to the fiftieth day. This time course of K+ channel development was clos ely related to allodynia and hyperalgesia of neuropathic animal behavi our. The results suggest that chronic contraction injury induces a dyn amic change in the ectopic mechanically activated channels and K+ chan nels at the injury site of nerve and there is an interchange in the de velopment time courses of the mechanically activated channels and K+ c hannels.