DETERMINATION OF MEFENAMIC-ACID AND PARACETAMOL BY FIRST DERIVATIVE SPECTROPHOTOMETRY

A direct and simple first derivative spectrophotometric method has bee n developed for the determination of mefenamic acid and paracetamol in pharmaceutical formulations. A methanolic hydrochloric acid solution was used as solvent for extracting the drugs from the formulations and subsequently the samples were evaluated directly by derivative spectr ophotometry. Simultaneous determination of both drugs can be carried o ut using the zero-crossing and the graphical methods. The methods do n ot require simultaneous equations to be solved. The calibration graphs were linear in the ranges from 1.8x 10(-6) to 1.6 x 10(-4) M of mefen amic acid and from 4.1 x 10(-6) to 1.4 x 10(-4) M of paracetamol. The ingredients commonly found in commercial pharmaceutical formulations d o not interfere. The proposed method was applied to the determination of these drugs in tablets.