T-PA ACTIVITY AND ANTIGEN IN THROMBOLYTIC TREATMENT WITH RT-PA IN CHILDREN

Authors
RISSEEUWAPPEL IM DEKKER I STIGTER RL VANKESSELBAKVIS CL
Citation
Im. Risseeuwappel et al., T-PA ACTIVITY AND ANTIGEN IN THROMBOLYTIC TREATMENT WITH RT-PA IN CHILDREN, Fibrinolysis, 10, 1996, pp. 57-58
Citations number
4
Categorie Soggetti
Hematology
Journal title
Fibrinolysis → ACNP
ISSN journal
02689499
Volume
10
Year of publication
1996
Supplement
2
Pages
57 - 58
Database
ISI
SICI code
0268-9499(1996)10:<57:TAAAIT>2.0.ZU;2-9
Abstract
The effect of increasing doses of rt-PA (Alteplase) in catheter relate d thrombi in children was studied. The data suggest that optimal local fibrinolytic treatment is realized at a systemic level of 0.80 ng/ml of t-PA, which was reached with a dosis of 0.10 mg/kg hour directly in fused via the affected catheter. After the introduction of rt-PA the l evel of PAI-1 activity immediately fell below 2 IU/ml, whereas the amo unt of PAI-1 antigen stayed at the same level throughout rt-PA treatme nt.