TRANSDERMAL NICOTINE ON SLEEP AND PGO SPIKES

Authors
VAZQUEZ J GUZMANMARIN R SALINPASCUAL RJ DRUCKERCOLIN R
Citation
J. Vazquez et al., TRANSDERMAL NICOTINE ON SLEEP AND PGO SPIKES, Brain research, 737(1-2), 1996, pp. 317-320
Citations number
28
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
737
Issue
1-2
Year of publication
1996
Pages
317 - 320
Database
ISI
SICI code
0006-8993(1996)737:1-2<317:TNOSAP>2.0.ZU;2-6
Abstract
There is conflicting evidence for the role of nicotine in sleep regula tion. This study was undertaken to determine the effects of transderma l nicotine at doses of 17.5, 35 and 52.5 mg on sleep and PGO spike act ivity. Minor effects were observed on sleep with a general increase in waking. PGO spike activity was abolished by all patches. The results are discussed in terms of the mechanisms involved in the disappearance of PGO spikes as a result of nicotine.