T. Yamazaki et al., ELEVATION OF EITHER AXOPLASMIC NOREPINEPHRINE OR SODIUM-LEVEL INDUCEDRELEASE OF NOREPINEPHRINE FROM CARDIAC SYMPATHETIC-NERVE TERMINALS, Brain research, 737(1-2), 1996, pp. 343-346
Using dialysis technique, prominent accumulation of norepinephrine (NE
) in the myocardial interstitial space was observed under two differen
t conditions: (I) local administration of a monoamine oxidase inhibito
r (pargyline, 1, 10 mM), (2) local administration of a Na,K-ATPase inh
ibitor(ouabain, 10, 100 mu M). Further, pretreatment with a vesicle up
take inhibitor (reserpine, 10 mu M) augmented these responses. Either
condition independently caused endogenous NE release and a brisk incre
ase in dialysate NE levels might occur as a a consequence of non-exocy
totic release of NE.