Lymph nodes involvement in AIDS is quite frequent and related to HN et
iopathogeny, besides it may be a complication of opportunistic infecti
ons and tumoral causes. Usually there is no difficulty in performing p
eripheral biopsies under local anesthesia because of sistemic widespre
ad distribution of adenomegalia. Some cases, however, may need more ag
gressive proceedings due to local deep adenopathy, e.g. in mediastinum
. Since 1993 mediastinoscopy was performed in 11 patients, all of them
them presenting mediastinal evidence of enlarged lymph nodes at CT. M
ain clinical manifestations were fever and prostration. There were no
complications related to the procedure. Microbiologic and histologic e
xaminations revealed tuberculosis (4 cases), atypical mycobacteriosis
(2 patients), funghi (2) and lymphoma (3 cases). In 8 patients other o
perative procedures with diagnostic aim were simultaneously performed
(concerning lung and/or liver diseases). Differences in etiology betwe
en the involved organs in a same patient were found in 6 cases. We con
clude that the mediastinum must be considered as a possible site of lo
cal adenopathy in AIDS patients, deserving surgical exploration if nec
essary. Mediastinoscopy has low morbidity and high diagnostic yield al
lowing an efficient and precise treatment.