ZD0870 TREATMENT OF MURINE CANDIDIASIS CAUSED BY FLUCONAZOLE RESISTANT ISOLATES OF CANDIDA-ALBICANS

Mice were infected intravenously with three fluconazole susceptible an d ten fluconazole resistant isolates of Candida albicans then treated with escalating doses of 0.25, 0.5, 1, 2.5, 10 and 40 mg/kg/day of the new antifungal triazole, ZD0870, for 10 days. A minimum protective do se of <0.25 mg/kg was determined for infections introduced by the thre e fluconazole susceptible C. albicans and one of the fluconazole resis tant isolates whereas doses ranging from 2.5 to 10 mg/kg/day were requ ired for infections induced by seven of the resistant isolates and gre ater than or equal to 40 mg/kg/day for the remainder. Thus, infections caused by fluconazole resistant C. albicans may be successfully treat ed with ZD0870, though higher doses than those used to treat infection s due to susceptible yeast may be required.