S. Lhopital et al., IN-VITRO ACTIVITY OF TEICOPLANIN AND CEFTRIAXONE IN COMBINATION AGAINST PATHOGENS INVOLVED IN PEDIATRIC BONE AND JOINT INFECTIONS, Journal of antimicrobial chemotherapy, 38(4), 1996, pp. 713-718
We investigated the combination of teicoplanin and ceftriaxone for its
bactericidal activity against Staphylococcus aureus, Haemophilus infl
uenzae type b and Streptococcus pneumoniae isolated from bone and join
t infections in children. An increase in bactericidal activity was obs
erved against isolates of S. aureus and H. influenzae when the antibio
tics were tested at fractional MICs whereas indifference was observed
at their MICs. Similar results were obtained at fractional MICs agains
t S. pneumoniae, but the bactericidal activity fell by more than 1 x l
og 10 cfu/mL when the antibiotics were tested at or above their MICs.