IN-VITRO ACTIVITY OF TEICOPLANIN AND CEFTRIAXONE IN COMBINATION AGAINST PATHOGENS INVOLVED IN PEDIATRIC BONE AND JOINT INFECTIONS

We investigated the combination of teicoplanin and ceftriaxone for its bactericidal activity against Staphylococcus aureus, Haemophilus infl uenzae type b and Streptococcus pneumoniae isolated from bone and join t infections in children. An increase in bactericidal activity was obs erved against isolates of S. aureus and H. influenzae when the antibio tics were tested at fractional MICs whereas indifference was observed at their MICs. Similar results were obtained at fractional MICs agains t S. pneumoniae, but the bactericidal activity fell by more than 1 x l og 10 cfu/mL when the antibiotics were tested at or above their MICs.