ASSOCIATION BETWEEN LONG-TERM KIDNEY GRAFT-SURVIVAL AND THE PRESENCE OF PRETRANSPLANT CYTOTOXIC ANTI-HLA AND OR NON-MHC FC-GAMMA-RII BLOCKING (ANTI-TLX) ALLOANTIBODY/

One hundred kidney graft recipients were analysed retrospectively with regard to the presence of Fc gamma RII (EAI) blocking or cytotoxic HL A antibody induced by pretransplant transfusion. Previous studies sugg ested that transfusion induces the production of EAI blocking antibody which may have specificity to TLX/CD46/MCP alloantigens. A superior g raft survival (65%/9 yr) was found in the presence of EAI alloantibody compared to graft survival in the absence of this antibody (40%/9 yr) . Further analysis showed the following survival rates in relation to the combined appearance of HLA cytotoxic and EAI antibody (EAI positiv e, HLA negative 67%/9 yr; EAI positive, HLA positive 60%/9 yr; EAI neg ative, HLA positive 0%/9 yr; EAI negative, HLA negative 40%/9 yr). The re was striking low graft failure in the first 6 months in patients wi th EAI antibody. Taking into consideration that the HLA B/DR mismatchi ng grade in all various groups were the same and no considerable diffe rence was found in association to graft survival, the presence or abse nce of alpha EAI (anti-TLX) antibody solely seems to have superior or additional effect on graft survival as compared to HLA matching.