PHARMACEUTICAL APPLICATIONS OF CYCLODEXTRINS .2. IN-VIVO DRUG-DELIVERY

The objective of this Review is to summarize and critique recent findi ngs and applications of both unmodified and modified cyclodextrins for in viva drug delivery. This review focuses on the use of cyclodextrin s for parenteral, oral, ophthalmic, and nasal drug delivery. Other rou tes including dermal, rectal, and pulmonary delivery are also briefly addressed. This Review primarily focuses on newer findings concerning cyclodextrin derivatives which are likely to receive regulatory accept ance due to improved aqueous solubility and safety profiles as compare d to ?he unmodified cyclodextrins. Many of the applications reviewed i nvolve the use of hydroxypropyl-beta-cyclodextrins (HP-beta-CDs) and s ulfobutylether-beta-cyclodextrins (SBE-beta-CDs) which show promise of greater safety while maintaining the ability to form inclusion comple xes, The advantages and limitations of HP-beta-CD, SBE-beta-GD, and ot her cyclodextrins are addressed.