Drug abuse has been controversially linked to polyarteritis nodosa. A
28-year-old man with a history of drag abuse with inhaled heroin prese
nted with an enigmatic illness consisting of refractory fever, bilater
al pleural effusions, migratory polyarthritis, and a leukaemoid reacti
on. An abdominal angiography confirmed diagnosis of polyarteritis nodo
sa, treatment with both prednisone and cyclophosphamide resulted in si
gnificant clinical and laboratory improvement.