SLEEP CYCLE DISTURBANCES INDUCED BY APAMIN, A SELECTIVE BLOCKER OF CA2-ACTIVATED K+ CHANNELS()

Authors
GANDOLFO G SCHWEITZ H LAZDUNSKI M GOTTESMANN C
Citation
G. Gandolfo et al., SLEEP CYCLE DISTURBANCES INDUCED BY APAMIN, A SELECTIVE BLOCKER OF CA2-ACTIVATED K+ CHANNELS(), Brain research, 736(1-2), 1996, pp. 344-347
Citations number
23
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
736
Issue
1-2
Year of publication
1996
Pages
344 - 347
Database
ISI
SICI code
0006-8993(1996)736:1-2<344:SCDIBA>2.0.ZU;2-9
Abstract
Intracerebroventricular injections of low doses of apamin, a specific blocker of a class of Ca2+-activated K+ channels, induced insomnia and a long-lasting suppression of deep slow sleep and paradoxical sleep. Injected animals showed a late but important rebound of paradoxical sl eep. Even after the recovery of a normal sleep amount, the circadian c ycle remained disturbed during all the recording duration (96 h).