THE D-2 DOPAMINE-RECEPTOR GENE AS A DETERMINANT OF REWARD DEFICIENCY SYNDROME

Citation
K. Blum et al., THE D-2 DOPAMINE-RECEPTOR GENE AS A DETERMINANT OF REWARD DEFICIENCY SYNDROME, Journal of the Royal Society of Medicine, 89(7), 1996, pp. 396-400
Citations number
66
Categorie Soggetti
Medicine, General & Internal
ISSN journal
01410768
Volume
89
Issue
7
Year of publication
1996
Pages
396 - 400
Database
ISI
SICI code
0141-0768(1996)89:7<396:TDDGAA>2.0.ZU;2-I
Abstract
The dopaminergic system, and in particular the dopamine D-2 receptor, has been profoundly implicated in reward mechanisms in the brain, Dysf unction of the D-2 dopamine receptors leads to aberrant substance seek ing behaviour (alcohol, drug, tobacco, and food) and other related beh aviours (pathological gambling, Tourette's syndrome, and attention def icit hyperactivity disorder). We propose that variants of the D-2 dopa mine receptor gene are important common genetic determinants of the 'r eward deficiency syndrome'.