ERYTHROPOIETIN-1994 - SELECTED ASPECTS OF CLINICAL RELEVANCE

Introduction of recombinant human erythropoietin into routine therapy of renal anemia has substantially enriched our knowledge of the pathog enesis of the uremic syndrome. This review summarizes up-to-date infor mation on clinically relevant selected aspects of long-term EPO therap y of uremic anemia. Among others the following topics are discussed:EP O-induced hypertension and increased blood coagulation, resistance to EPO, effect of EPO on endocrine organs, and optimalization of EPO dosi ng.