HYPOTENSIVE RESUSCITATION

While the mechanism remains unclear, a growing body of experimental an d clinical evidence suggests that aggressive crystalloid resuscitation in near fatal uncontrolled hemorrhage is associated with poor outcome . Limited attempts to restore blood pressure improve cardiac output, t issue perfusion, and survival while attempts to restore normal tension with crystalloid result in increased hemorrhage volume and higher mor tality. The current standard of therapy for treatment of hemorrhagic s hock includes initial aggressive crystalloid resuscitation. This mini- review summarizes some of the experimental and clinical data suggestin g that this approach may not be desirable in the presence of uncontrol led hemorrhage following injury.