THE STRUCTURE OF LACTATE-DEHYDROGENASE FROM PLASMODIUM-FALCIPARUM REVEALS A NEW TARGET FOR ANTIMALARIAL DESIGN

Authors
DUNN CR BANFIELD MJ BARKER JJ HIGHAM CW MORETON KM TURGUTBALIK D BRADY RL HOLBROOK JJ
Citation
Cr. Dunn et al., THE STRUCTURE OF LACTATE-DEHYDROGENASE FROM PLASMODIUM-FALCIPARUM REVEALS A NEW TARGET FOR ANTIMALARIAL DESIGN, Nature structural biology, 3(11), 1996, pp. 912-915
Citations number
20
Categorie Soggetti
Biology,"Cell Biology
Journal title
Nature structural biology → ACNP
ISSN journal
10728368
Volume
3
Issue
11
Year of publication
1996
Pages
912 - 915
Database
ISI
SICI code
1072-8368(1996)3:11<912:TSOLFP>2.0.ZU;2-V
Abstract
The crystal structure of Plasmodium falciparum lactate dehydrogenase r eveals a surprising shift in the position of the NADH cofactor that ex plains the unusual biochemical properties of this enzyme. There is als o a distinctive surface cleft adjacent to the NADH binding pocket that forms an attractive target for inhibitor design.