CAPILLARY ELECTROCHROMATOGRAPHY IN THE PHARMACEUTICAL-INDUSTRY - PRACTICAL REALITY OR FANTASY

Rapid and highly efficient separations of pharmaceutical compounds can be achieved by capillary electrochromatography (CEC) in analyses whic h are quantitative, reproducible and robust. Columns prepared by packi ng with a supercritical fluid were highly efficient and gave repeatabl e, quantitative and sensitive separations, Pressurization of the syste m and control of column temperature mere necessary to prevent bubble f ormation. The concept of isoeluotropic strength was shown to apply in CEC. Applications to pharmaceutical compounds are described.